Code Blue and Gold

The quarterly newsletter of the University of Pittsburgh Department of Medicine

December 2025 – March 2026

Aging Institute

Doshi NK, Pesaresi T, Pagadala T, Dion W, Zhang Y, David NL, Amorim T, Wang W, Kumar GVN, Zhu B, Liu S, Patwari P, Fazeli PK, Steinhauser ML. Branched chain amino acids prime metabolic inflammation. Mol Metab. 2026 Feb;104:102308. PMID: 41407040; PMCID: PMC12818990.

Tan JX, Lv B, Li J, Li T, Du F, Chen X, Zhang X, Bai XC, Chen ZJ. PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling. Nature. 2026 Feb 4. PMID: 41639454.
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Yadav S, Pan X, Li S, Martin PL, Hoang N, Chen K, Karhadkar A, Malhotra J, Zuckerman AL, Munan S, Klose MK, Wang L, Cracan V, Parkhitko AA. Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes. Sci Adv. 2026 Jan 2;12(1):eady0628. PMID: 41481756; PMCID: PMC12758502.

Cardiology

Gokhale TA, Dey S, Limpitikul WB, Gautam N, Al’Aref SJ, Cross B, Saba S, Estes NAM 3rd, Vaughan BL, Jones SR, Tomaselli GF, Wu KC, DeMazumder D. Combined Analysis of Cardiac Repolarization Entropy and Magnetic Resonance Imaging Enhances Risk Stratification of Patients Receiving a Primary-Prevention ICD. JACC Clin Electrophysiol. 2026 Feb 24:S2405-500X(26)00126-X. PMID: 41823943.

Howard A, Kancharla K, Aronis KN, Bhonsale A, Voigt AH, Dhande M, Jain SK, Estes M, Saba SF, Shalaby AA. A simplified method of lead snaring to facilitate a tandem approach for long-dwelling transvenous lead extractions. Heart Rhythm. 2026 Mar;23(3):e420-e427. PMID: 41422928.

McNamara DM, Cooper LT, Friedrich MG, Arbel Y, Bhimaraj A, Bocchi E, Hamer A, Herdy AH, Kerneis M, Liu PP, Parker AB, Pocock SJ, Smith ER, Tang WHW, Torre-Amione G, Tschöpe C; ARCHER Study Group. Impact of cannabidiol on myocardial recovery in patients with acute myocarditis: primary results of the ARCHER study. ESC Heart Fail. 2026 Feb 3;13(1):xvaf034. PMID: 41711722.

Classical Hematology

Brzoska T, Kaminski TW, Katoch O, Menchikova EV, Alagbe AE, Tashbook SE, Tofovic SP, Jonassaint JC, St Croix CM, Watkins SC, Howe S, Field JJ, Seyerle AA, Pradhan-Sundd T, Laurie C, Pankratz ND, Smith NL, Goode EL, Pankow JS, Kooperberg C, Kato GJ, Zhang Y, Novelli EM, Gladwin MT, Jackson EK, Nouraie SM, Sundd P. CD39 polymorphism enables lung thrombosis in sickle cell disease. Nat Commun. 2026 Jan 14;17(1):1693. PMID: 41530145; PMCID: PMC12909804.
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Nahle T, Shah V, Farraj SA, Atoui A. Next-generation T cell engagers in oncology: Pharmacologic evolution from bispecific to trispecific antibodies. J Pharmacol Exp Ther. 2025 Dec;392(12):103704. PMID: 41478662; PMCID: PMC12799530.

Santini T, Li J, Liou JJ, Wood S, Aizenstein HJ, Mettenburg J, Novelli EM, Ibrahim TS, Oluwole O. Accelerated brain atrophy in sickle cell anemia despite chronic exchange transfusion therapy-A case report. Radiol Case Rep. 2026 Jan 31;21(4):1642-1646. PMID: 41675069; PMCID: PMC12886526.

Endocrinology and Metabolism

Amorim T, David NL, Moturi S, Turnquist LR, Holmes TM, Bouxsein ML, Fazeli PK. Effects of teriparatide on hip structure and bone microarchitecture in women with anorexia nervosa: a placebo-controlled randomized trial. Osteoporos Int. 2026 Jan 27. PMID: 41591404.

Hadley CK, Galgano L, Gui Y, Carvalho da Silva AM, Porter DT, Wu Y, Lai Y, Torti M, Çakır I. The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition. Nat Commun. 2026 Feb 5;17(1):1212. PMID: 41644943; PMCID: PMC12877105.
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Mendes TB, Miller RG, Toledo FGS. Hydroxychloroquine alters lipoprotein particle concentrations and composition. J Clin Lipidol. 2026 Jan 23:S1933-2874(26)00013-9. PMID: 41708458; PMCID: PMC12917314.

Gastroenterology, Hepatology and Nutrition

Chaudhary S, Liu JJ, Liu S, Di M, Beier JI, Bataller R, Argemi J, Benos PV, Arteel GE. α-Diversity analysis of hepatic transcriptome reveals distinct pathways in alcohol-associated hepatitis. JCI Insight. 2026 Jan 8;11(5):e200727. PMID: 41505218.
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Coté GA, Durkalski-Mauldin V, Fogel EL, Moffatt DC, Wang AY, Lara LF, Tarnasky PR, Buxbaum JL, Dai SC, Jonnalagadda S, Willingham FF, Ross A, Keswani RN, Inamdar S, Kothari TH, Gardner TB, Jamidar PA, Gaddam S, Pleskow DK, Easler JJ, Elmunzer BJ, Coneys JG, Mallery JS, Strand DS, Papachristou GI, Slivka A, Kedia P, Sahakian AB, Kouanda A, Phan A, Williams A, Andersen DK, Serrano J, Yadav D; SHARP Consortium. Minor Papillotomy for Treatment of Idiopathic Acute Pancreatitis With Pancreas Divisum: A Randomized Clinical Trial. JAMA. 2026 Feb 24;335(8):682-692. PMID: 41533371; PMCID: PMC12805493.
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Das R, Kleinberger J, Sawas T, Wald AI, Bubar R, Singh H, Chennat J, Khalid A, Romutis SL, Rabinovitz M, Tavakkoli A, Fairley KJ, Boone BA, Sarkaria S, Nasr J, Thiruvengadam NR, Gabbert C, Mahmood S, Messallam AA, Gjeorgjievski M, Goldschmiedt M, Thakkar S, Tielleman T, Dugum M, Reich J, Singh S, Brand RE, McGrath K, Fasanella K, Lennon AM, Reddy R, Shrestha R, Ellis DJ, Singhi SA, Lee T, Kay PS, Lee RD, Chua TY, Nassour I, Buxbaum JL, Law JK, Bhat Y, Jamidar PA, Jonica ER, Easler JJ, Skef W, Vanderveldt HD, Dasyam AK, Geller DA, Zureikat AH, Zeh HJ, Polanco PM, Marsh JW, Hogg M, Lee KK, Pingpank JF, Choudry MHA, Humar A, Schmidt C, Mansour J, Nunns G, Ongchin M, Paniccia A, Lajara S, Monaco SE, Ohori NP, Pantanowitz L, Mitchell JM, Smith K, Shaker N, Singhi AH, Hsu D, Saeed A, Sahin IH, Zhang J, Gorantla V, Rhee J, Nikiforova MN, Kubiliun N, Slivka A, Singhi AD. DNA/RNA-based next-generation sequencing (NGS) improves the early diagnosis and management of neopl…. Gastroenterology. 2026. 
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General Internal Medicine

Hamm ME, Emerson R, Rogal SS, Bulls HW, Nugent SM, Anderson A, Nash S, Salay M, Winstanley EL, de Abril Cameron F, DeMonte W, Debi P, Choo LY, Chan B, Weintraub E, Bachrach RL, van Oppen D, Edwards KA, Merlin JS. Tailoring of a chronic pain self-management intervention for individuals with opioid use disorder in office-based addiction treatment. J Subst Use Addict Treat. 2026 Jan 31;185:209910. PMID: 41628668.
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Quinn DA, Hutchins F, Sileanu FE, Procario GT, Mor MK, Rosland AM, Katon JG, Callegari LS, Borrero S. Classifying Veterans’ pre-pregnancy health risks using latent class analysis. Womens Health (Lond). 2026 Jan-Dec;22:17455057261430209. PMID: 41845905.

Russell LE, Frank DA, Purkayastha S, McCoy JL, Leder SM, Gordon JH, Lamba S, Procario GT, Moy EM, Hausmann LRM. Racial, Ethnic, and Sex Differences in Social Risks and Social Needs Concordance Among Veterans. JAMA Netw Open. 2026 Feb 2;9(2):e2559892. PMID: 41701493; PMCID: PMC12914491.

Geriatric Medicine

Enyioha C, Gorstein L, Clark S, Goldstein AO, Vilardaga R, Hightow-Weidman LB, Kistler CE. Features of mHealth Apps for Tobacco Cessation Important to Black Adults: Discrete Choice Experiment. JMIR Form Res. 2026 Mar 13;10:e83919. PMID: 41824745; PMCID: PMC12987408.

Forman DE, Perera S, Shiva S, Glynn NW, Stakich TS, Ramos SV, Distefano G, Wolf C, Kendi A, Sterczala AJ, Sipula IJ, Bello FM, Jurczak MJ, Sciurba FC, Gladwin MT, Newman AB, Coen PM. Benefits of oral nitrite supplementation on mitochondrial respiration and physical function in older adults. J Gerontol A Biol Sci Med Sci. 2026 Mar 10;81(4):glag034. PMID: 41691463.

Haeri NS, Perera S, Greenspan SL. Bridging diagnostic gaps in osteoporosis and sarcopenia in long-term care: Leveraging a mobile assessment unit for clinical trials and comprehensive musculoskeletal evaluations. J Clin Densitom. 2026 Jan-Mar;29(1):101664. PMID: 41506026; PMCID: PMC12818468.

Infectious Diseases

Bhise A, Chu X, Josefsson A, Cortez AG, Diehl G, Rigatti LH, Park HJ, Nedrow JR, Li W. Fc-Engineering Improves PET Imaging of Anti-Mesothelin VH-Fc across Multiple Tumor Mouse Models and Reveals Sex-Specific Renal Clearance. Bioconjug Chem. 2026 Jan 21;37(1):192-202. PMID: 41439681; PMCID: PMC12828721.

Fleres G, Cheng S, Badrane H, Dupont CL, Espinoza JL, Abbey D, Driscoll E, Newbrough A, Hao B, Mansour A, Nguyen MH, Clancy CJ. Blood Cultures Contain Populations of Genetically Diverse Candida albicans Strains that May Differ in Echinocandin Tolerance and Fitness. J Infect Dis. 2026 Mar 17;233(3):560-572. PMID: 41026105.

Park JH, Chen E, Joseph DE, Wanger A, Viehman JA, Padival S. Prevalence and Risk Factors for Non-HACEK Gram-negative Bacillus Endocarditis: A Retrospective Analysis. Can J Cardiol. 2026 Mar;42(3):610-619. PMID: 41475616.

Malignant Hematology and Medical Oncology

Ge H, Li H, Kulkarni A, Chen Z, Upadhyay P, Ferris RL, Wang JH. Pre-existing TCR clones drive major pathological responses in HNSCC patients treated with dual immune checkpoint inhibitors. Clin Cancer Res. 2026 Mar 5. PMID: 41785014.

Ito S, Martin E, Panousis C, Rowe AM, Stras S, Roy J, Cofano EB, Ventura K, Parr K, Neupane B, Bellesis A, Toki A, Jing R, Jang J, Neves AT, Shlomchik MJ, Shlomchik WD. High-throughput cloning reveals diverse properties of T-cell receptors targeting minor histocompatibility antigens. Blood Adv. 2026 Feb 24;10(4):1114-1125. PMID: 41170916; PMCID: PMC12915166.

Panesso-Gómez S, Cole AJ, Arrigo A, Roberts A, Bello M, Wield A, Anyaeche VI, McGonigal S, Hijazi A, Shah J, Jiang Q, Ebai T, Sharrow AC, Tseng G, Yoon E, Brown DD, Clark AM, Larsen SD, Eder I, Gau D, Roy P, Tran L, Jiang H, Sannino S, Goeckler-Fried J, Choi Y, Brodsky JL, Osmanbeyoglu H, Ma X, Dahl KN, McAuliffe PF, Lee AV, Buckanovich RJ. Identification of the MRTFA/SRF pathway as a critical regulator of quiescence and chemotherapy resistance in cancer. Cancer Lett. 2026 Mar 12;646:218435. PMID: 41831517.

Pulmonary, Allergy, Critical Care, and Sleep Medicine

Moghbeli K, Popescu I, Iasella CJ, Lieber S, Snyder ME, Sciullo M, Koshy R, Zeng A, Mohanty RP, Langelier C, Lendermon EA, Shah R, Johnson B, Zhu D, Martinu T, Leard LE, Kleinhenz ME, Hays SR, Singer JP, Shigemura N, Pilewski JM, Hage CA, Chen K, Greenland JR, McDyer JF. Immune gene correlation networks differentiate both chronic lung allograft dysfunction and survival. Am J Transplant. 2026 Feb 10:S1600-6135(26)00047-X. PMID: 41679649.

Prendergast NT, Onyemekwu CA, Toth KM, Franz CA, Kitsios GD, McVerry BJ, Pandharipande PP, Ely EW, Girard TD. Derivation and validation of a prediction rule for sedative-associated delirium during acute respiratory failure requiring mechanical ventilation. J Crit Care. 2026 Apr;92:155407. PMID: 41477971.

Valenzi E, Jia M, Gerges P, Fan J, Tabib T, Behera R, Mao H, Xue D, Ju EM, Zhou Y, Sembrat JC, Das J, Benos PV, Singh H, Lafyatis R. Altered AP-1, RUNX, and EGR chromatin dynamics drive human fibrotic lung disease. Ann Rheum Dis. 2025 Dec 31:S0003-4967(25)04598-4. PMID: 41478761.

Renal-Electrolyte

Bondi CD, Hartman HL, Gilbert JL, Stewart JA, Clayton DR, Tan RJ. Tubular Epithelia-Specific Deletion of MCP-1 Does Not Afford Protection Against Adriamycin-Induced Kidney Injury. Int J Mol Sci. 2026 Mar 6;27(5):2432. PMID: 41828647; PMCID: PMC12986468.

Orandi BJ, Urbanski M, Fallahzadeh MK, Budhiraja P, Balaraman V, Butsch WS, Morford H, Anand PM, Woodside KJ, Puttarajappa CM. Obesity Care Barriers in Kidney Transplant Candidates and Recipients: Perspectives from a Survey of Transplant Experts. Obes Facts. 2026 Jan 19:1-7. PMID: 41553952; PMCID: PMC12952905.

Weltman MR, Lavenburg LU, Neilesh Kenkre B, Alexander L, Gul A, Bursic AE, Amarapurkar P, Hamm ME, Jhamb M. Primary Care Provider Perceptions of a Population Health Management Program to Improve Kidney Care: A Mixed Methods Study. J Gen Intern Med. 2026 Feb 11. PMID: 41670882.

Rheumatology and Clinical Immunology

Glassberg MK, Burg C, Pereira-Simon S, Trzaskoma B, Harlow L, Biedka S, Elliot S, Zhang Y, VanEvery H, Fertig N, Minden JS, Ascherman DP. Revisiting the INSPIRE trial: antibody profiling reveals high prevalence of occult autoimmunity. Respir Res. 2026 Jan 20;27(1):64. PMID: 41559617; PMCID: PMC12895703.

Li Y, Dey I, Vyas SP, Synackova A, Li D, Lubberts E, Ascherman DP, Draber P, Gaffen SL. The RNA binding protein Arid5a is an activator of TNF signaling in rheumatoid arthritis. JCI Insight. 2026 Jan 23;11(2):e196411. PMID: 41574607; PMCID: PMC12892899.

Sattui SE, Bertolet M, Forman DE, Danielson ME, Yao S, Lopez OL, Glynn NW, Nadkarni NK, Sekikawa A, Bruno TC, Finkel T, Newman AB. The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study-Concept, Rationale, and Design. J Am Geriatr Soc. 2026 Mar;74(3):636-647. PMID: 41518612; PMCID: PMC12968359.

Vascular Medicine Institute

Kelly NJ, Chaudhary R, El Khoury W, Kalepalli N, Wang J, Patel P, Chan IN, Rahman H, Saiyed A, Shah AN, McClung CA, Okawa S, Nouraie SM, Chan SY. Health outcomes after national acute sleep deprivation events among the American public. JCI Insight. 2025 Dec 23;11(3):e195344. PMID: 41433114; PMCID: PMC12892888.

Vasamsetti SB, Sadaf S, Uddin MA, Shen J, Johny E, Mondal A, Florentin J, Lei L, Mannan A, Rao KS, Sembrat J, Rojas M, Sipula I, Kastroll J, Jurczak MJ, Shiva S, O’Doherty RM, Yechoor V, Dutta P. Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation. Nat Commun. 2026 Feb 12;17(1):1493. PMID: 41680163; PMCID: PMC12902017.
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Yeh YS, Huang J, Liu Z, Cosme C Jr, Zhang X, Razani B. Cytosolic Versus Lysosomal Lipolysis in Adipose Tissue: Opposing Roles in Cardiometabolic Disease. Arterioscler Thromb Vasc Biol. 2026 Feb;46(2):e323273. PMID: 41431923; PMCID: PMC12758639.

Internal Medicine Residency

Bejjani A, Khairani CD, Krishnathasan D, Rizzo SM, Sato A, Bacare B, Scimeca G, Tristani A, Armero A, Porio N, Bikdeli B, Piazza G. The link between venous thromboembolism and atherothrombosis: epidemiology, pathophysiology, and implications for clinical care. Eur Heart J Acute Cardiovasc Care. 2026 Jan 23;14(12):756-768. PMID: 40825545.

Jain V, Swadley M, Brozovich M, Mahmood S. Endoscopic mesorectal dissection for precise pathologic staging and potential treatment of locally advanced rectal cancer. VideoGIE. 2025 Aug 21;11(3):90-93. PMID: 41837268; PMCID: PMC12988412.

Pressimone C, Cao C, Kyle J, Vanderberg R. Understanding essential aspects of fibromyalgia care through a qualitative study of patient feedback. PEC Innov. 2026 Mar 6;8:100466. PMID: 41858999; PMCID: PMC12997196.