Code Blue and Gold

The quarterly newsletter of the University of Pittsburgh Department of Medicine

Publications

1 June 2024 - 1 September 2024

Aging Institute

Wu Y, Jiang D, Liu Q, Yan S, Liu X, Wu T, Sun W, Li G. Cathepsin L induces cellular senescence by upregulating CUX1 and p16INK4a. Aging (Albany NY). 2024 Jun 18;16(13):10749-10764. PMID: 38944813; PMCID: PMC11272106.

Yadav S, Graham A, Al Hammood F, Garbark C, Vasudevan D, Pandey U, Asara JM, Rajasundaram D, Parkhitko AA. Unique tau- and synuclein-dependent metabolic reprogramming in neurons distinct from normal aging. Aging Cell. 2024 Aug 13:e14277. PMID: 39137949.

Zhu B, Liu S, David NL, Dion W, Doshi NK, Siegel LB, Amorim T, Andrews RE, Kumar GVN, Li H, Irfan S, Pesaresi T, Sharma AX, Sun M, Fazeli PK, Steinhauser ML. Evidence for ~12-h ultradian gene programs in humans. NPJ Biol Timing Sleep. 2024;1(1):4. PMID: 39148626; PMCID: PMC11325440.

Cardiology

Bhonsale A, Zhu J, Thoma F, Kancharla K, Voigt A, Estes NA, Shalaby AA, Saba S, Mulukutla S, Jain S. Impact of Weight Gain on Cardiovascular Outcomes in Patients With Atrial Fibrillation. J Am Heart Assoc. 2024 Jul 2;13(13):e032550. PMID: 38934853; PMCID: PMC11255690.

Countouris ME, Shapero KS, Swabe G, Hauspurg A, Davis EM, Magnani JW. Association of Race and Ethnicity and Social Factors With Postpartum Primary Care or Cardiology Follow-Up Visits Among Individuals With Preeclampsia. J Am Heart Assoc. 2024 Aug 20;13(16):e033188. PMID: 39109511.
>> Read more about this publication here.

Koczo A, Reza N, Hayes SN, Freed BH, Gulati M, Merz NB, Berlacher K, Sunthankar K, Tamirisa KP. Beyond Parental Leave: Addressing Infertility, Pregnancy, and Postpartum Complications Among Cardiologists. JACC Adv. 2024 Aug 21;3(10):101213. PMID: 39252858; PMCID: PMC11381826.

Classical Hematology

Ragni MV, Mead H, de Jong YP, Kaczmarek R, Leavitt AD, Long B, Nugent D, Sabatino DE, Fong S, von Drygalski A MD, Walsh CE, Luxon B. Optimizing Liver Health Before and After Gene Therapy for Hemophilia A. Blood Adv. 2024 Jun 6:bloodadvances.2024013059. PMID: 38843379.

Chen Q, Hazra R, Crosby D, Lenhart D, Lenhart SC, Mondal P, Zhang Y, Nouraie SM, Tan RJ, Esmon CT, Rao LVM, Kim K, Ghosh S. Heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice. Blood. 2024 Aug 1;144(5):552-564. PMID: 38820589; PMCID: PMC11307268.
>> Read more about this publication here and here.

Sasi P, Makubi A, Sangeda RZ, Ngaeje MY, Mmbando BP, Soka J, Rosano C, Magesa AS, Cox SE, Makani J, Novelli EM. Hydroxyurea mobile directly observed therapy versus standard monitoring in patients with sickle cell anemia: a phase 2 randomized trial. Commun Med (Lond). 2024 Aug 9;4(1):160. PMID: 39122788; PMCID: PMC11315961.

Endocrinology and Metabolism

Zamora Z, Lui LY, Sparks LM, Justice J, Lyles M, Gentle L, Gregory H, Yeo RX, Kershaw EE, Stefanovic-Racic M, Newman AB, Kritchevsky S, Toledo FGS. Percutaneous biopsies of skeletal muscle and adipose tissue in individuals older than 70: methods and outcomes in the Study of Muscle, Mobility and Aging (SOMMA). Geroscience. 2024 Jun;46(3):3419-3428. PMID: 38315316; PMCID: PMC11009187.

Negi V, Lee J, Mandi V, Danvers J, Liu R, Perez-Garcia EM, Li F, Jagannathan R, Yang P, Filingeri D, Kumar A, Ma K, Moulik M, Yechoor VK. Bromodomain Protein Inhibition Protects β-Cells from Cytokine-Induced Death and Dysfunction via Antagonism of NF-κB Pathway. Cells. 2024 Jun 26;13(13):1108. PMID: 38994961; PMCID: PMC11240345.

Teng L, Dedousis N, Adeshirlarijaney A, Kanshana JS, Liu M, Hodges CA, Kohan AB. Impaired intestinal free fatty acid transport followed by chylomicron malformation, not pancreatic insufficiency, cause metabolic defects in cystic fibrosis. J Lipid Res. 2024 Jul;65(7):100551. PMID: 39002195; PMCID: PMC11301217.

Gastroenterology, Hepatology and Nutrition

Mohy-Ud-Din N, Lin FP, Rachakonda V, Al-Khafaji A, Biggins SW, Ganesh S, Bataller R, DiMartini A, Hughes C, Humar A, Malik SM. Expedited liver transplantation as first-line therapy for severe alcohol hepatitis: ELFSAH; deferring corticosteroids in the sickest subset of patients. Clin Transplant. 2024 Jul;38(7):e15340. PMID: 39049597.

Ertem FU, Rivers CR, Ghaffari AA, Watson AR, Tang G, Schwartz M, Johnston E, Barrie A, Harrison J, Dueker JM, Hartman D, Binion DG. Efficacy of Ustekinumab and Vedolizumab Among Postoperative Crohn’s Disease Patients as Postoperative Prophylaxis and Rescue Therapy: Real-world Data. Inflamm Bowel Dis. 2024 Jul 2:izae137. PMID: 38953641.

Griffin NE, Ferrell M, Feldman R, Dasyam AK, Slivka A, Khalid A, Singh H, Gabbert C, Das R, Mahmood S, Rabinovitz M, Chennat J, Romutis S, Klem ML, Yadav D, Phillips AE. Natural history of spontaneous pancreatic portal vein fistulae: A systematic review of the literature. Pancreatology. 2024 Sep;24(6):870-877. PMID: 39147659.

General Internal Medicine

Jones KF, Long DM, Bair MJ, Agil D, Browne L, Burkholder G, Clay OJ, Conder K, Durr AL, Farel CE, King K, Johnson B, Liebschutz JM, Demonte W, Leone M, Mullen L, Orris SM, Thomas T, Johnson M, Napravnik S, Merlin JS. Efficacy of a Pain Self-Management Intervention Tailored to People With HIV: A Randomized Clinical Trial. JAMA Intern Med. 2024 Sep 1;184(9):1074-1082. PMID: 39008317; PMCID: PMC11250263.
>> Read more about this publication here

Sekar DR, Ehrenberger KA, Dakroub A, Rothenberger S, Grau T, Carter AE. What/Why/When/Where/How Framework and Faculty Development Workshop to Improve the Utility of Narrative Evaluations for Assessing Internal Medicine Residents. MedEdPORTAL. 2024 Jul 30;20:11420. PMID: 39081631; PMCID: PMC11286767.

Anderson TS, Wilson LM, Sussman JB. Atherosclerotic Cardiovascular Disease Risk Estimates Using the Predicting Risk of Cardiovascular Disease Events Equations. JAMA Intern Med. 2024 Aug 1;184(8):963-970. PMID: 38856978; PMCID: PMC11165411.
>> Read more about this publication here.

Geriatric Medicine

Bej TA, Wilson BM, El Chakhtoura N, Perez F, Jump RLP. Change in Provider Specialty Was Associated With Less Fluoroquinolone Use at a Veterans Affairs Long-Term Care Setting. J Am Med Dir Assoc. 2024 Jun;25(6):104927. PMID: 38320741.

Kistler CE, Inoue M, Matsui T, Abe M, Le Donne M, Kiyota A, Lin FC, Yang Y, Hanson LC. Pre-post-evaluation of a dementia-specific advance care planning toolkit for Japanese primary care clinicians. J Am Geriatr Soc. 2024 Jun 19. PMID: 38895937.

Tighe CA, Phares A, Weiner DK, Beehler GP, VanSwearingen J, Harvey AG, Hilgeman MM, Buysse DJ, Forman DE. Adapting and Evaluating the Feasibility and Acceptability of a Behavioral Intervention to Promote Sleep Health in Cardiac Rehabilitation. Behav Sleep Med. 2024 Aug 9:1-16. PMID: 39120442.

Infectious Diseases

Karunakaran S, Pless LL, Ayres AM, Ciccone C, Penzelik J, Sundermann AJ, Martin EM, Griffith MP, Waggle K, Hodges JC, Harrison LH, Snyder GM. Impact of discontinuation of contact precautions on surveillance- and whole genome sequencing-defined methicillin-resistant Staphylococcus aureus healthcare-associated infections. Antimicrob Steward Healthc Epidemiol. 2024 Jun 4;4(1):e97. PMID: 38836046; PMCID: PMC11149034.

Shah S, Kline EG, Haidar G, Squires KM, Pogue JM, McCreary EK, Ludwig J, Clarke LG, Stellfox M, Van Tyne D, Shields RK. Rates of resistance to ceftazidime-avibactam and ceftolozane-tazobactam among patients treated for multidrug-resistant Pseudomonas aeruginosa bacteremia or pneumonia. Clin Infect Dis. 2024 Jun 21:ciae332. PMID: 38902935.

Morris BC, Hixson EA, Klamar-Blain C, Gillespie DG, Abebe KZ, Rinaldo CR, Mellors JW, Jackson EK, Riddler SA, Macatangay BJC. Attenuation of HIV-Specific T Cell Responses Among People with HIV on art Following Dipyridamole Treatment. J Leukoc Biol. 2024 Aug 31:qiae192. PMID: 39217408.

Malignant Hematology and Medical Oncology

Nacev BA, Dabas Y, Paul MR, Pacheco C, Mitchener M, Perez Y, Fang Y, Soshnev AA, Barrows D, Carroll T, Socci ND, St Jean SC, Tiwari S, Gruss MJ, Monette S, Tap WD, Garcia BA, Muir T, Allis CD. Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation. Nat Commun. 2024 Jun 17;15(1):5155. PMID: 38886411; PMCID: PMC11183192.

Rastogi P, Bandos H, Lucas PC, van ‘t Veer LJ, Wei JJ, Geyer CE Jr, Fehrenbacher L, Chia SKL, Brufsky AM, Walshe JM, Soori GS, Dakhil SR, Paik S, Swain SM, Menicucci AR, Audeh MW, Wolmark N, Mamounas EP. Utility of the 70-Gene MammaPrint Assay for Prediction of Benefit From Extended Letrozole Therapy in the NRG Oncology/NSABP B-42 Trial. J Clin Oncol. 2024 Jul 24:JCO2301995. PMID: 39047219.

Frisbie L, Pressimone C, Dyer E, Baruwal R, Garcia G, St Croix C, Watkins S, Calderone M, Gorecki G, Javed Z, Atiya HI, Hempel N, Pearson A, Coffman LG. Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer. Cell Rep. 2024 Aug 27;43(8):114551. PMID: 39067022; PMCID: PMC11420855.

Pulmonary, Allergy, Critical Care, and Sleep Medicine

Kitsios GD, Sayed K, Fitch A, Yang H, Britton N, Shah F, Bain W, Evankovich JW, Qin S, Wang X, Li K, Patel A, Zhang Y, Radder J, Dela Cruz C, Okin DA, Huang CY, Van Tyne D, Benos PV, Methé B, Lai P, Morris A, McVerry BJ. Longitudinal multicompartment characterization of host-microbiota interactions in patients with acute respiratory failure. Nat Commun. 2024 Jun 3;15(1):4708. PMID: 38830853; PMCID: PMC11148165.

Patel SR. Entering a New Era in Sleep-Apnea Treatment. N Engl J Med. 2024 Jun 21. PMID: 38912659.

Allbright K, Villandre J, Crotty Alexander LE, Zhang M, Benam KH, Evankovich J, Königshoff M, Chandra D. The paradox of the safer cigarette: understanding the pulmonary effects of electronic cigarettes. Eur Respir J. 2024 Jun 28;63(6):2301494. PMID: 38609098.

Renal-Electrolyte

Jhamb M, Weltman MR, Devaraj SM, Lavenburg LU, Han Z, Alghwiri AA, Fischer GS, Rollman BL, Nolin TD, Yabes JG. Electronic Health Record Population Health Management for Chronic Kidney Disease Care: A Cluster Randomized Clinical Trial. JAMA Intern Med. 2024 Jul 1;184(7):737-747. PMID: 38619824; PMCID: PMC11019443.

Wang XP, Mutchler SM, Carrisoza-Gaytan R, Nickerson AJ, Baty CJ, Al-Bataineh M, Vandevender A, Morimoto T, Srinivasan P, Tan RJ, Jurczak MJ, Satlin LM, Kashlan OB. Epithelial Na + Channel Activation after Bile Duct Ligation with Mineralocorticoid Receptor Blockade. J Am Soc Nephrol. 2024 Jul 10. PMID: 38986682.

Youm EB, Shipman KE, Albalawy WN, Vandevender AM, Sipula IJ, Rbaibi Y, Marciszyn AE, Lashway JA, Brown EE, Bondi CB, Boyd-Shiwarski CR, Tan RJ, Jurczak MJ, Weisz OA. Megalin Knockout Reduces SGLT2 Expression and Sensitizes to Western Diet-induced Kidney Injury. Function (Oxf). 2024 Jul 11;5(4):zqae026. PMID: 38984983; PMCID: PMC11237895.

Rheumatology and Clinical Immunology

Gordon RA, Cosgrove HA, Marinov A, Gingras S, Tilstra JS, Campbell AM, Bastacky SI, Kashgarian M, Perl A, Nickerson KM, Shlomchik MJ. NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7. JCI Insight. 2024 Jul 23;9(16):e178563. PMID: 39042716; PMCID: PMC11343599.
>> Watch the video abstract here.

Yamaguchi K, Poland P, Zhu L, Moghadam-Kia S, Aggarwal R, Maeno T, Uchiyama A, Motegi SI, Oddis CV, Ascherman DP. Comparative B cell epitope profiling in Japanese and North American cohorts of MDA5+ dermatomyositis reveals a direct association between immune repertoire and pulmonary mortality. Rheumatology (Oxford). 2024 Aug 26:keae466. PMID: 39186037.

Li Y, Vyas SP, Mehta I, Asada N, Dey I, Taylor TC, Bechara R, Amatya N, Aggor FEY, Coleman BM, Li DD, Yamamoto K, Ezenwa O, Sun Y, Sterneck E, McManus CJ, Panzer U, Biswas PS, Savan R, Das J, Gaffen SL. The RNA binding protein Arid5a drives IL-17-dependent autoantibody-induced glomerulonephritis. J Exp Med. 2024 Sep 2;221(9):e20240656. Epub 2024 Jul 26. PMID: 39058386; PMCID: PMC11284280.

Vascular Medicine Institute

Rachedi NS, Tang Y, Tai YY, Zhao J, Chauvet C, Grynblat J, Akoumia KKF, Estephan L, Torrino S, Sbai C, Ait-Mouffok A, Latoche JD, Al Aaraj Y, Brau F, Abélanet S, Clavel S, Zhang Y, Guillermier C, Kumar NVG, Tavakoli S, Mercier O, Risbano MG, Yao ZK, Yang G, Ouerfelli O, Lewis JS, Montani D, Humbert M, Steinhauser ML, Anderson CJ, Oldham WM, Perros F, Bertero T, Chan SY. Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness. Cell Metab. 2024 Jun 4;36(6):1335-1350.e8. PMID: 38701775; PMCID: PMC11152997.

Kudryashova TV, Jiang L, Goncharova EA. What Is All of the Hype About? Hypusine Signaling as a Driver of Pulmonary Hypertension. Am J Respir Crit Care Med. 2024 Jun 1;209(11):1298-1300. PMID: 38412504; PMCID: PMC11146570.

Natarajan N, Florentin J, Johny E, Xiao H, O’Neil SP, Lei L, Shen J, Ohayon L, Johnson AR, Rao K, Li X, Zhao Y, Zhang Y, Tavakoli S, Shiva S, Das J, Dutta P. Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis. Nat Commun. 2024 Aug 26;15(1):7337. PMID: 39187565; PMCID: PMC11347661.
>> Read more about this publication here.

Internal Medicine Residency

Shi Y, Taherifard E, Saeed A, Saeed A. MASLD-Related HCC: A Comprehensive Review of the Trends, Pathophysiology, Tumor Microenvironment, Surveillance, and Treatment Options. Curr Issues Mol Biol. 2024 Jun 13;46(6):5965-5983. PMID: 38921027; PMCID: PMC11202630.

Niezen S, Noll A, Bamporiki J, Rogal SS. Management of fatigue and sleep disorders in patients with chronic liver disease. Clin Liver Dis (Hoboken). 2024 Jun 21;23(1):e0122. PMID: 38911999; PMCID: PMC11191865.

Reddy A, Hauspurg A, Venkatakrishnan K, Pippi D, Lemon L, Berlacher K, Jeyabalan A, Countouris M. Establishing a Remote Blood Pressure Monitoring Program Through the First Year Postpartum After Pregnancy-Induced Hypertension. JACC Adv. 2024 Aug 14;3(9):101189. PMID: 39238849; PMCID: PMC11375256.
>> Read more about this publication here.