Grants
1 June 2024 - 1 September 2024
Kaleab Abebe, PhD, Linda Fried, MD, MPH, and Paul Palevsky, MD (with Sandra Kane-Gill, PharmD) // General Internal Medicine and Renal-Electrolyte
The Pittsburgh Scientific and Data Research Center for the COPE-AKI Consortium (Pitt-SDRC)-Supplement
U01 DK130010 Supplement
Start Date: August 1, 2024
End Date: June 30, 2026
Total Annual Costs: $265,067
Mohammad Al-Bataineh, DVM, PhD // Renal-Electrolyte
Role of MUC1 in the host defense against urinary tract infection
R01 DK135862 First R01
Start Date: June 10, 2024
End Date: April 30, 2029
Total Annual Costs: $585,993
Jonathan Alder, PhD // Pulmonary, Allergy, Critical Care, and Sleep Medicine
Mechanisms of Telomere-Mediated Lung Disease
R01 HL135062
Start Date: July 10, 2018*
End Date: June 30, 2028
Total Annual Costs: $735,366
Cristian Apetrei, MD, PhD (with Ivona Vasile Pandrea, MD, PhD) // Infectious Diseases
Assessing the Role of GI Tract Dysfunction to HIV/SIV Disease Progression
R01 DK113919
Start Date: May 1, 2017*
End Date: April 30, 2029
Total Annual Costs: $665,909
Jason Becker, MD // Cardiology and VMI
Cardiomyocyte selective modulation of natriuretic peptide signaling in cardiomyopathy
R01 HL169784
Start Date: July 9, 2024
End Date: June 30, 2028
Total Annual Costs: $653,854
Mehret Birru Talabi, MD, PhD (with Dara Méndez, PhD, MPH, and Hyagriv Simhan, MD, MS) // Rheumatology and Clinical Immunology
Equity in Maternal and Birthing Outcomes and Reproductive HeAlth through Community Engagement
U54 HD113030
Start Date: June 26, 2024
End Date: May 31, 2030
Total Annual Costs: $2,154,648
>> Read more about this grant
Divay Chandra, MD, MSc // Pulmonary, Allergy, Critical Care, and Sleep Medicine
Developing Lithium as a Disease-Modifying Therapy
ALA Airways Clinical Research Centers Network
Start Date: July 1, 2024
End Date: June 30, 2026
Total Annual Costs: $47,500
Divay Chandra, MD, MSc, and Sally Wenzel, MD (with Jessica Bon, MD, MS) // Pulmonary, Allergy, Critical Care, and Sleep Medicine
2024 Pittsburgh International Lung Conference: From Smog to Social Equity: How the Exposome Shapes Our Respiratory Health
R13 HL176036
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $35,000
Yu-Chiao Chiu, PhD // Malignant Hematology and Medical Oncology
Novel computational approaches for pharmacogenomics of complex diseases
R35 GM154967
Start Date: September 1, 2024
End Date: August 31, 2029
Total Annual Costs: $385,700
Wei Du, MD, PhD // Malignant Hematology and Medical Oncology
Role of LAM-specific TREM1 in leukemogenesis
R01 CA285400
Start Date: August 9, 2024
End Date: July 31, 2029
Total Annual Costs: $517,618
Oliver Eickelberg, MD, and Marta Bueno, PhD // Pulmonary, Allergy, Critical Care, and Sleep Medicine
Role of plasma cells in chronic rejection after lung transplantation
R01 HL172493 First R01 for Dr. Bueno
Start Date: September 2, 2024
End Date: May 31, 2028
Total Annual Costs: $747,239
Ning Feng, MD, PhD // Cardiology and VMI
Epigenetic reprogramming of cardiac macrophages to promote cardiac regeneration
AHA Innovative Project Award, 24IPA1274021
Start Date: July 1, 2024
End Date: June 30, 2026
Total Annual Costs: $100,000
Sarah Gaffen, PhD // Rheumatology and Clinical Immunology
Mucosal host defense against vaginal candidiasis
R21 AI185365
Start Date: June 21, 2024
End Date: April 30, 2026
Total Annual Costs: $236,730
Chadi Hage, MD (with Jiantao Pu, PhD, and Pablo Sanchez, MD, PhD) // Pulmonary, Allergy, Critical Care, and Sleep Medicine
An Automated Frailty Scoring System for Lung Transplantation Based on Bio-Geo-Composition
R01 HL174570 First R01
Start Date: August 15, 2024
End Date: May 31, 2028
Total Annual Costs: $449,041
Yufei Huang, PhD (with Shou-Jiang Gao, PhD) // Malignant Hematology and Medical Oncology
Novel geometric deep learning models for tissue structure-aware spatial expression representations from spatially resolved single-cell transcriptomics data
R21 GM155774
Start Date: September 1, 2024
End Date: August 31, 2026
Total Annual Costs: $198,750
Yufei Huang, PhD // Malignant Hematology and Medical Oncology
m6A-suite: an informatics pipeline and resource for elucidating roles of m6A epitranscriptome in cancer
U01 CA279618 Supplement
Start Date: June 1, 2024
End Date: March 31, 2026
Total Annual Costs: $206,303
Manisha Jhamb, MD, MPH (with Mark Unruh, MD, MS) // Renal-Electrolyte
Technology Assisted Collaborative Care Implementation Trial
R01 DK114085
Start Date: July 5, 2017*
End Date: May 31, 2029
Total Annual Costs: $694,969
Manisha Jhamb, MD, MPH, and Thomas Kleyman, MD (with Jacqueline Ho, MD, MSc) // Renal-Electrolyte
PCT-KUH: Pittsburgh Center for Training in Kidney, Urology and Hematology
U2C DK136783/TL1 DK143271
Start Date: September 1, 2024
End Date: May 31, 2029
Total Annual Costs: $873,331
>> Read more about this new training program
Michael Jurczak, PhD // Endocrinology and Metabolism
Insulin resistance and glucose toxicity in CFRD
Cystic Fibrosis Foundation
Start Date: September 1, 2024
End Date: August 31, 2026
Total Annual Costs: $130,408
Daniel Kass, MD // Pulmonary, Allergy, Critical Care, and Sleep Medicine
Mirador Collaboration
Mirador Therapeutics SRA00004900
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $335,690
Tamar Krishnamurti, PhD (with Bryan Wilder, PhD) // General Internal Medicine
SCH: Machine learning for personalized preventative intervention in perinatal depression
R01 MH139097
Start Date: September 1, 2024
End Date: June 30, 2028
Total Annual Costs: $277,767
Robert Lafyatis, MD // Rheumatology and Clinical Immunology
Pathways regulating profibrotic macrophages in a novel explant model of systemic sclerosis-associated interstitial lung disease
R21 AR084251
Start Date: September 6, 2024
End Date: August 31, 2026
Total Annual Costs: $199,496
Jessica Merlin, MD, PhD, MBA, and Erin Winstanley, PhD // General Internal Medicine
Building an interprofessional and diverse workforce in substance use and pain
T32 DA057926
Start Date: July 1, 2024
End Date: June 30, 2029
Total Annual Costs: $202,337
>> Read more about this new training program
Barbara Methé, PhD, Georgios Kitsios, MD, PhD, and Alison Morris, MD, MS (with N. Luisa Hiller, PhD) // Pulmonary, Allergy, Critical Care, and Sleep Medicine
The Third Pittsburgh Rust Belt Microbiome Conference
R13 AI186418
Start Date: August 5, 2024
End Date: July 31, 2025
Total Annual Costs: $5,000
Hiam Naiditch, MD // Pulmonary, Allergy, Critical Care, and Sleep Medicine
Examining Racial Disparities in Predictive Modeling Among Survivors of Critical Illness
F32 MD019534
Start Date: July 1, 2024
End Date: June 30, 2026
Total Annual Costs: $90,932
Patrick Pagano, PhD (with Alberto Vazquez, PhD) // VMI
NOX2 Small Molecule Inhibitors as a Therapeutic Strategy in the Treatment of Alzheimer’s Disease
R21 AG089718
Start Date: September 1, 2024
End Date: May 31, 2026
Total Annual Costs: $198,750
Anuradha Ray, PhD, and Prabir Ray, PhD // Pulmonary, Allergy, Critical Care, and Sleep Medicine
Mechanisms of Antigen-Induced Tolerance in the Lung
R01 AI176632
Start Date: June 12, 2024
End Date: April 30, 2029
Total Annual Costs: $592,242
Doris Rubio, PhD (with Ronald Idoko) // General Internal Medicine
Promoting Inclusive Excellence
R01 GM155395
Start Date: September 1, 2024
End Date: May 31, 2029
Total Annual Costs: $879,690
>> Read more about this grant on PittWire
Jami Saloman, PhD // Gastroenterology, Hepatology and Nutrition
Peripheral Nerve Regulation of Pancreas Cancer Progression
R01 CA285585
Start Date: July 1, 2024
End Date: June 30, 2029
Total Annual Costs: $622,548
Leslie Scheunemann, MD, MPH // Geriatric Medicine
PIC-TRFS: A Randomized Trial of a Multicomponent Intervention for ICU Survivors and Caregivers
R01 HS029870 First R01
Start Date: June 1, 2024
End Date: March 31, 2029
Total Annual Costs: $399,993
Maryam Sharifi-Sanjani, PhD // Cardiology and VMI
Telomeric Protein Trf2: the Regulator of Right Ventricular Dysfunction in Pulmonary Hypertension
AHA Transformational Project Award, 24TPA1301061
Start Date: July 1, 2024
End Date: June 30, 2027
Total Annual Costs: $100,000
Cynthia St. Hilaire, PhD // Cardiology and VMI
Telomerase Reverse Transcriptase in Aortic Valve Calcification
R56 HL168657
Start Date: August 1, 2024
End Date: July 31, 2025
Total Annual Costs: $750,345
Matthew Steinhauser, MD // Cardiology and Aging Institute
Defining the molecular regulation and physiological role of a novel lysosomal mechanism of adipocyte lipolysis
R01 DK137913
Start Date: September 10, 2024
End Date: May 31, 2029
Total Annual Costs: $538,357
Madison Stellfox, MD, PhD // Infectious Diseases
Genetic and phenotypic adaptations of vancomycin-resistant Enterococcus faecium during recurrent bloodstream infection
K08 AI185312
Start Date: July 25, 2024
End Date: June 30, 2029
Total Annual Costs: $171,089
Jeremy Tilstra, MD, PhD // Rheumatology and Clinical Immunology
Evaluating the Parenchymal IFN response in Lupus Nephritis
Rheumatology Research Foundation, Career Development Bridge Funding Award
Start Date: August 1, 2024
End Date: July 31, 2026
Total Annual Costs: $100,000
Daria Van Tyne, PhD // Infectious Diseases
Optimization of activity and improved delivery of bacteriophages targeting Burkholderia spp.
Cystic Fibrosis Research Institute New Horizons Program
Start Date: August 1, 2024
End Date: July 31, 2025
Total Annual Costs: $70,000
Daria Van Tyne, PhD // Infectious Diseases
Adaptation of vancomycin-resistant enterococci during bloodstream infection
R01 AI165519 Supplement
Start Date: June 24, 2024
End Date: May 31, 2025
Total Annual Costs: $87,870
Flordeliza Villanueva, MD // Cardiology
Ultrasound-targeted Microbubble Cavitation
Focused Ultrasound Foundation
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $100,000
Dhiraj Yadav, MD, MPH (with Yogish Kudva, MBBS) // Gastroenterology, Hepatology and Nutrition
Parallel-group randomized controlled trial of Pioglitazone versus empagliflozin for T3cDM: The PEP-DM Trial
R01 DK137868
Start Date: August 1, 2024
End Date: May 31, 2027
Total Annual Costs: $333,445
Manling Zhang, MD, MS // Cardiology and VMI
Mettl14 mediated mRNA methylation orchestrates postnatal cardiac development
R03 HL174881
Start Date: August 26, 2024
End Date: July 31, 2026
Total Annual Costs: $119,250
KARAT Catalytic Grants
Ning Feng, MD, PhD // Cardiology and VMI
DNA demethylase Tet3 promotes myocardial Genimic DNA stability
KARAT Catalytic Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $40,000
The Role of TRPM6 in Lactation-Associated Renal Tubular Mg2+ Conservation
KARAT Catalytic Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $40,000
Evaluating the Effect of Ketones in Hypoxic Congenital Cardiomyopathy
KARAT Catalytic Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $40,000
Dan Shiwarski, PhD // VMI
Developing a 3D Bioengineered Microphysiological Vascular system to Study WNK Droplets Regu
KARAT Catalytic Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $40,000
Impact of recipient age on chronic lung allograft dysfunction in a murine model of orthotopic lung transplant
KARAT Catalytic Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $40,000
Regulation of ER stress during Klebsiella pneumoniae infection of the lung
KARAT Catalytic Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $40,000
Functional SNP regulatory proteins in systemic sclerosis
KARAT Catalytic Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $40,000
Decoding the Regulatory Roles of Dilated Cardiomyopathy SNPs
KARAT Catalytic Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $40,000
KARAT Bridge Grants
Anabolic-androgenic steroid-induced FSGS
KARAT Bridge Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Deep phenotyping renal allograft biopsies to prognosticate acute rejection
KARAT Bridge Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Proteotoxic Stress in Sepsis
KARAT Bridge Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Nutrient-limited translation during colon cancer metastatic progression
KARAT Bridge Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Niranjana Natarajan, PhD // Rheumatology and Clinical Immunology
Role of Gpr107 in macrophage to fibroblast paracrine signaling in heart failure
KARAT Bridge Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Chethan Puttarajappa, MD, MS // Renal-Electrolyte
T-cell Responses to EBV in Adult Kidney Transplant Recipients
KARAT Bridge Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
The effect of Plasmalogen Supplementation on Lipid and Inflammatory Biofluid Markers and Subclinical Atherosclerosis: A Pilot Study
KARAT Bridge Grant
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
McKamish Family Foundation Cardiovascular Innovator Awards
Cynthia St. Hilaire, PhD (with Ibrahim Sultan, MD) // Cardiology and VMI
Mechanisms Dictating Canonical VS Non-Canonical Functions of Tert
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $50,000
Brett Kaufman, PhD, and Flordeliza Villaneuva, MD // Cardiology and VMI
In Vivo Delivery of γPNAs by Ultrasound-targeted Microbubble Cavitation
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $50,000
Xiangyu Zhang, PhD, and Anum Saeed, MD // Cardiology
Cholesterol-mTOR Nexus: Dissecting the Impact of Hypercholesterolemia on Lysosomal Degradation Pathways in Humans
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $50,000
Daniel Shiwarski, PhD, and Anita Saraf, MD, PhD // Cardiology and VMI
Development of a Full-biologic 3D Bioprinted Hepatic Sinusoid Model for Improved Risk Stratification of Thrombosis Burden in Fontan-treated Single-ventricle Patients
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $50,000
Lucy Zhang, MD, PhD, and Michael Risbano, MD, MA // Pulmonary, Allergy, Critical Care, and Sleep Medicine and VMI
Pathogenic Mechanism and Novel Therapeutic Strategy for Exercise Intolerance in Post-Acute Sequelae of COVID-19
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Anita Saraf, MD, PhD, and Neil Kelly, MD, PhD // Cardiology and VMI
Evaluating the Effect of Ketones in Hypoxic Congenital Cardiomyopathy
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Saifur Rahman Khan, PhD, and Anum Saeed, MD // Cardiology and VMI
CERS2 Deletion and Its Loss-of-Function Polymorphism-Induced Atherosclerotic Dyslipidermia: A Pathway from Type 2 Diabetes to Atherosclerotic Cardiovascular Disease
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Tanmay Gokhale, MD, PhD (with Deeptankar DeMazumder, MD, PhD) // Cardiology
Machine Learning-Based Longitudinal Analysis of Serial ECGs for Prediction of Sudden Death
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Agnes Koczo, MD, and Adam Straub, PhD // Cardiology and VMI
CRB5R3 T117S Variant Contribution to NO-cGC-cGMP Mediated Coronary Vascular Dysfunction and Cardiac Hypertrophy in Non-Ischemic and Peripartum Cardiomyopathy
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Winters Foundation Awards
Matthew Culyba, MD, PhD // Infectious Diseases
Role of the Staphylococcus aureus DNA damage (SOS) response during infection
Winters Foundation
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Anurag Paranjape, PhD // Cardiology
Heart Remodeling and miR-92a: Unraveling Molecular Insights for Therapeutic Advancements
Winters Foundation
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Saifur Rahman Khan, PhD // Cardiology and VMI
The role and mechanism of CERS2 and its risk allele in T2D pathogenesis
Winters Foundation
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
Jesus Tejero Bravo, PhD // Pulmonary, Allergy, Critical Care, and Sleep Medicine and VMI
Development of engineered carbon monoxide-oxidizing enzymes for treatment of carbon monoxide poisoning
Winters Foundation
Start Date: September 1, 2024
End Date: August 31, 2025
Total Annual Costs: $10,000
* Competitively renewed