Code Blue and Gold

The quarterly newsletter of the University of Pittsburgh Department of Medicine

The Center for Immunometabolism (CIM), directed by Babak Razani, MD, PhD, offers a suite of scientific cores designed to help investigators explore the intersection of metabolism and immunity. These shared resources provide access to state-of-the-art technologies, specialized expertise, and collaborative support making it easier for researchers to take their work from early discovery through translational impact.

Immune Phenotyping Unit

Led by Xiangyu Zhang, PhD, this unit supports the detailed analysis of immune cells. Services include flow cytometry, cell sorting, immunofluorescence, and confocal microscopy, tools that allow researchers to characterize cell populations, signaling pathways, cytokine expression, and metabolic dysfunction with precision.

Bioinformatics & Metabolomics Unit

Directed by Md Saifur Rahman Khan, PhD, this unit provides expertise in the analysis and integration of multi-omics data. From genomics and proteomics to metabolomics and single-cell sequencing, the team applies advanced computational methods, including machine learning, to uncover new mechanisms and potential biomarkers.

Cellular Metabolism Unit

Under the direction of Yu-Sheng Yeh, PhD, RD, this core offers in vivo and in vitro platforms to investigate mechanisms of energy balance and metabolic disease. Capabilities range from rodent models of obesity and insulin resistance to Seahorse assays that measure mitochondrial respiration, glycolysis, and fatty acid oxidation.

Lipid Metabolism Unit

Directed by Sonia Salvatore, this unit focuses on lipid biology and its role in regulating immunity and metabolism. Researchers can leverage specialized assays and analyses to study how lipids influence energy regulation, inflammation, and disease progression.

Clinical & Translational Studies Core

Directed by Ali Ajam, MD, this core connects basic science to human health. It provides support for clinical and observational studies, including IRB navigation, recruitment of diverse patient cohorts, biospecimen collection, and integration of clinical data with laboratory findings.

Together, CIM’s scientific cores make it possible for researchers to answer complex questions that span molecular, cellular, animal, and human systems. Whether you’re testing a new hypothesis, generating pilot data, or moving toward translational applications, these resources are here to strengthen and accelerate your research.

Learn more about available services and how to access these cores at: cim.pitt.edu/scientific-cores